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LDL reduction→plaque stabilization→carotid IMT regression
Atorvastatin reduces carotid intima-media thickness and reverses plaque progression through lipid lowering and anti-inflammatory pleiotropic effects; clinical studies confirm significant reversal and delay of carotid atherosclerosis. This is a user-priority domain with direct clinical evidence. Note: 'carotid artery diseases' and 'carotid artery stenosis' are in the approved list but 'carotid atherosclerosis' as a specific plaque-regression endpoint is a distinct off-label research focus.
“Evaluation of the atorvastatin effect on carotid atherosclerosis in patients with type 2 diabetes mellitus by assessing the lipid peroxidation marker 8-isoprostaglandin F2α dynamic”
— Evaluation of the atorvastatin effect on carotid atherosclerosis in patients with type 2 diabetes mellitus by assessing the lipid peroxidation marker 8-isoprostaglandin F2α dynamic (2020)DOI“A retrospective cohort study on the clinical efficacy of Shanhuang Jiangzhi tablets and Atorvastatin calcium tablets in the treatment of carotid atherosclerosis.”
— A retrospective cohort study on the clinical efficacy of Shanhuang Jiangzhi tablets and Atorvastatin calcium tablets in the treatment of carotid atherosclerosis. (2025)DOI“Therefore, this study aims to verify the efficacy and immunomodulatory effects of atorvastatin combined with amlodipine in the treatment of hypertension combined with carotid atherosclerosis.”
— Effects of amlodipine combined with atorvastatin on Th17/Treg imbalance and vascular microcirculation in hypertensive patients with atherosclerosis: A double-blind, single-center randomized controlled trial. (2023)DOI“To evaluate the efficacy of atorvastatin combined with febuxostat in the treatment of gout patients with carotid atherosclerosis and to observe the effects on serum tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and C-reactive protein (CRP) levels, carotid plaques, and the adverse reaction”
— Clinical study of different doses of atorvastatin combined with febuxostat in patients with gout and carotid atherosclerosis. (2020)DOI“Amlodipine combined with atorvastatin has a good therapeutic effect on patients with coronary heart disease complicated with carotid atherosclerosis and has good application value.”
— The Effect of Amlodipine Combined with Atorvastatin on the Levels of HMGB-1 and YKL-40 in Patients with Coronary Heart Disease and Carotid Atherosclerosis (2021)DOI“The purpose of the study is to investigate the clinical efficacy and long-term prognosis of acupuncture (AP) combined with atorvastatin (ATO) in treating senile essential hypertension (EH) complicated with carotid atherosclerosis (CA).”
— Additional Acupuncture Confers a Favorable Long-Term Prognosis for Elderly Hypertensive Patients with Carotid Atherosclerosis after Atorvastatin Treatment. (2022)DOI“Eighty-four statin-free subjects with non-significant, preclinical carotid atherosclerosis and elevated LDL- cholesterol levels (>130 mg/dl) were recruited to receive atorvastatin (from 10 to 80 mg per day) (atorvastatin group - AG group).”
— Omentin-1 and vaspin serum levels in patients with pre-clinical carotid atherosclerosis and the effect of statin therapy on them. (2020)DOI“Retracted: Additional Acupuncture Confers a Favorable Long-Term Prognosis for Elderly Hypertensive Patients with Carotid Atherosclerosis after Atorvastatin Treatment.”
— Retracted: Additional Acupuncture Confers a Favorable Long-Term Prognosis for Elderly Hypertensive Patients with Carotid Atherosclerosis after Atorvastatin Treatment. (2023)DOI