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Anti-angiogenic/antioxidant→retinal vascular protection
Atorvastatin may protect retinal vasculature in diabetes through anti-inflammatory and anti-angiogenic mechanisms, reducing VEGF-driven neovascularization and oxidative stress; the single preclinical study using streptozocin-induced DR with atorvastatin plus melatonin provides initial mechanistic evidence. This is a user-priority domain.
“The present study was designed to evaluate the effects of Atorvastatin (ATO) plus Melatonin (MEL) on streptozocin-induced Diabetic Retinopathy (DR) in rats.”
— Beneficial Effects of Melatonin and Atorvastatin on Retinopathy in Streptozocin-induced Diabetic Rats (2020)DOI“Purpose: To evaluate the effect of Atorvastatin on hard exudates in diabetic retinopathy in type 2 diabetic patients with normal lipid profile.”
— Effect of atorvastatin on hard exudates in type 2 diabetic patients with normal lipid profile (2020)DOI