Loading...
retinal neovascularization inhibition→microvascular protection
Statins may protect against diabetic retinopathy through reduction of retinal neovascularization, anti-inflammatory effects, and improvement of microvascular endothelial function. A systematic review and meta-analysis supports reduced incidence and improved visual outcomes. Evidence is primarily from observational studies and small clinical trials rather than large RCTs.
“Effect of lipid lowering agents (statin) on Diabetic retinopathy.”
— EFFECT OF STATIN USE ON STATUS OF DIABETIC ETINOPATHY/ DIABETIC MACULAR EDEMA IN PATIENTS OF TYPE 2 DIABETES MELLITUS (2021)DOI“CONCLUSION:- This study had shown improvement of visual acuity,decrease in macular edema and progression of diabetic retinopathy in patients whom statins was given The study also revealed that,the statins are effective in decreasing the total cholesterol(mean value during baseline was 154.13 mg/dl w”
— EFFECT OF STATIN USE ON STATUS OF DIABETIC ETINOPATHY/ DIABETIC MACULAR EDEMA IN PATIENTS OF TYPE 2 DIABETES MELLITUS (2021)DOI“Statin reduces the incidence of diabetic retinopathy and its need for intervention: A systematic review and meta-analysis.”
— Statin reduces the incidence of diabetic retinopathy and its need for intervention: A systematic review and meta-analysis. (2020)DOI“Statin was associated with a decreased risk of diabetic retinopathy and its subtypes.”
— Statin reduces the incidence of diabetic retinopathy and its need for intervention: A systematic review and meta-analysis. (2020)DOI“To compare the effects of intensive and standard statin therapy on severity of diabetic retinopathy (DR) complicated by hypercholesterolaemia in a prespecified substudy of the standard vs. intEnsive statin therapy for hypercholesteroleMic Patients with diAbetic retinopaTHY (EMPATHY) study.”
— Intensive treat-to-target statin therapy and severity of diabetic retinopathy complicated by hypercholesterolaemia. (2020)DOI“There are indications that statins may have a protective role against cataract formation, AMD, diabetic retinopathy progression, and non-infectious uveitis.”
— The Effect of Statins on Ocular Disorders: A Systematic Review of Randomized Controlled Trials. (2023)DOI“Fibrates, statins and α-cyclodextrin effectively dissolved CCs present in in vitro models of diabetic retinopathy, and prevented CC-induced endothelial pathology.”
— Cholesterol crystal formation is a unifying pathogenic mechanism in the development of diabetic retinopathy. (2023)DOI“Addition of fenofibrate to statins is associated with risk reduction of diabetic retinopathy progression in patients with type 2 diabetes and metabolic syndrome: a propensity-matched cohort study.”
— Addition of fenofibrate to statins is associated with risk reduction of diabetic retinopathy progression in patients with type 2 diabetes and metabolic syndrome: a propensity-matched cohort study. (2023)DOI“Dyslipidemia medications such as statins and fibrates may be associated with a reduction in diabetic retinopathy (DR) progression, but real-world data is lacking.”
— Impact of Dyslipidemia Medications on the Prevalence of Diabetic Retinopathy Among a Large US Cohort. (2023)DOI“Effects of genetically proxied statins on diabetic nephropathy and retinopathy: a Mendelian randomization study.”
— Effects of genetically proxied statins on diabetic nephropathy and retinopathy: a Mendelian randomization study. (2024)DOI“Association of Use of Statins with Progression of Diabetic Retinopathy at a Tertiary Care Hospital in Southern India.”
— Association of Use of Statins with Progression of Diabetic Retinopathy at a Tertiary Care Hospital in Southern India. (2022)DOI“Statin use and the risk of progression to vision threatening diabetic retinopathy.”
— Statin use and the risk of progression to vision threatening diabetic retinopathy. (2022)DOI