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anti-inflammatory→cytokine storm attenuation→endothelial protection
Statins may benefit COVID-19 patients through anti-inflammatory and immunomodulatory pleiotropic effects, reduction of cytokine storm, and improvement of endothelial dysfunction. Despite a 0% support ratio in co-mention analysis and 109 contradicting mentions, clinical analyses show cost-effectiveness and protective associations in hospitalized patients. Evidence is mixed and this remains an active research question.
“In this review, we provide a comprehensive description of the mechanisms of the pleotropic effects of statins, the relevant pre-clinical and clinical data pertinent to their role in infections and acute lung injury, the possible cardiovascular benefits of statins in COVID-19, and the implications of”
— Statins as an adjunctive therapy for COVID-19: the biological and clinical plausibility. (2021)DOI“The results obtained provide additional information to dissect the mechanism underlying the protective effects of statin use in COVID-19.”
— In Vitro Evidence of Statins' Protective Role against COVID-19 Hallmarks. (2022)DOI“This analysis demonstrated that treatment of hospitalized COVID-19 patients with statins was both cheaper and more effective than treatment without statins; statin-containing therapy dominates over non-statin therapy.”
— Cost-effectiveness analysis of statins for the treatment of hospitalized COVID-19 patients. (2022)DOI“Results: Treatment of hospitalized COVID-19 patients with statins was both cheaper and more effective than treatment without statins; statin-containing therapy dominates over non-statin therapy.”
— Cost-Effectiveness Analysis of Statins for Treatment of Hospitalized COVID-19 Patients (2021)DOI“Further investigation into statin is needed for more conclusive effects of statins for treatment of COVID-19.”
— The association between statin and COVID-19 adverse outcomes: national COVID-19 cohort in South Korea. (2022)DOI“We carried out a meta-analysis to investigate the effect of statins on 3 COVID-19 outcomes: intensive care unit (ICU) admission, tracheal intubation, and death.”
— Improved COVID-19 ICU admission and mortality outcomes following treatment with statins: a systematic review and meta-analysis. (2021)DOI