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NF-κB inhibition→cytokine storm attenuation in sepsis
Atorvastatin's pleiotropic immunomodulatory effects, including NF-κB inhibition and endothelial protection, may attenuate the cytokine storm and immune dysregulation in sepsis; a 2024 paper specifically addresses its effects on sepsis-related inflammation. This represents a novel repurposing opportunity with preclinical and early clinical evidence.
“Owing to its pleiotropic effects, atorvastatin, a clinical lipid-lowering drug, affects various aspects of sepsis-related inflammation and immune responses.”
— Atorvastatin combined with imipenem alleviates lung injury in sepsis by inhibiting neutrophil extracellular trap formation via the ERK/NOX2 signaling pathway. (2024)DOI“Among different types of statins, atorvastatin showed the most significant trend to reduce the risk of mortality in patients with sepsis.”
— Association between statin administration and outcome in patients with sepsis: A retrospective study. (2025)DOI“This ROS-responsive nano-drug delivery system combining mitochondria-targeting ceria nanoparticles with atorvastatin has favorable potentials in the sepsis-induced AKI therapy.”
— ROS-responsive nano-drug delivery system combining mitochondria-targeting ceria nanoparticles with atorvastatin for acute kidney injury. (2020)DOI“As statins decrease the progression of sepsis and its related mortality, this study aimed to evaluate the effect of atorvastatin on survival and symptom improvement in hospitalized patients with COVID-19.”
— Survival of the hospitalized patients with COVID-19 receiving atorvastatin: A randomized clinical trial. (2022)DOI“Being a sepsis-like disease, an anti-inflammatory drug as atorvastatin would reduce mortality and severity in COVID-19.”
— Atorvastatin For Reduction Of 28-Day Mortality In Hospitalized COVID-19 Patients: A Protocol For A Randomized, Double-Blinded, Placebo-Controlled, Clinical Trial (2022)DOI“After induced sepsis, all animals from the SEPSIS group were randomly divided into 4 subgroups: animals with induced sepsis without treatment (S), animals with induced sepsis treated with a single dose of Atorvastatin, Simvastatin, and Rosuvastatin.”
— The Effects of Statins on Cardiac Function and Oxidative Status in Rats with Sepsis (2021)DOI