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MMP inhibition→aortic wall inflammation reduction→aneurysm progression slowing
Statins may slow abdominal aortic aneurysm progression through anti-inflammatory effects, matrix metalloproteinase inhibition, and reduction of oxidative stress in the aortic wall. Evidence includes experimental animal studies and observational human data suggesting reduced aneurysm progression, with a 10% support ratio. Clinical efficacy remains controversial without definitive RCT evidence.
“The necessity and efficacy of statin treatment for abdominal aortic aneurysm (AAA) remains controversial.”
— Meta-analysis suggests statins reduce mortality after abdominal aortic aneurysm repair. (2021)DOI“Effect of statins on abdominal aortic aneurysm.”
— Effect of statins on abdominal aortic aneurysm. (2022)DOI“Statins have been shown to decrease aneurysm progression and rupture in two experimental settings: animals with cerebral aneurysm and humans with abdominal aortic aneurysms.”
— Statins and subarachnoid hemorrhage in Medicare patients with unruptured cerebral aneurysms. (2015)DOI“Their low cost, widespread availability, and strong safety profile tip the risk-to-benefit ratio toward statins for abdominal aortic aneurysms but more research is needed.”
— Aortopathy: Effects of Lipid-Lowering Therapy. (2023)DOI“Combination β- and renin-aldosterone-angiotensin blockade, statins, metformin, antioxidants, and vitamins have been evaluated as therapeutics in both thoracic and abdominal aortic aneurysms, as well as the effects of various antibiotics (ie, fluoroquinolones and tetracyclines) and benefits of lifest”
— An assessment of the current medical management of thoracic aortic disease: A patient-centered scoping literature review. (2022)DOI“Faculty Opinions recommendation of Statins reduce mortality after abdominal aortic aneurysm repair: A systematic review and meta-analysis.”
— Faculty Opinions recommendation of Statins reduce mortality after abdominal aortic aneurysm repair: A systematic review and meta-analysis. (2021)DOI“Statins prevent the progression of abdominal aortic aneurysm.”
— Statins prevent the progression of abdominal aortic aneurysm. (2025)DOI“Background: Main objective of this study was to evaluate the influence of statins and/or acetylsalicylic acid on biochemical characteristics of abdominal aortic aneurysm (AAA) wall and intraluminal thrombus (ILT).”
— Influence of preoperative statins and aspirin administration on biological and magnetic resonance imaging properties in patients with abdominal aortic aneurysm. (2020)DOI“The aim of this study was to investigate factors associated with a pharmacological preventive potential of statins and anti-platelet agents among attenders vascular screening for abdominal aortic aneurysm (AAA) and peripheral arterial disease (PAD).”
— Pharmacological Preventive Potential Among Attenders at Vascular Screening: Findings from the VIVA Trial. (2020)DOI“Mendelian randomization was utilized to analyze data from 500,000 participants in the UK Biobank to evaluate the effects of statins, PCSK9 inhibitors (PCSK9i), beta-blockers, and calcium channel blockers on the risks of thoracic aortic aneurysm (TAA), abdominal aortic aneurysm (AAA), and aortic diss”
— Lipid-Lowering and Antihypertensive Drugs on Aortic Disease Risk: Insights from Mendelian Randomization Analysis and Real-World Pharmacovigilance Data. (2025)DOI“Effect of Statins on Total Mortality in Abdominal Aortic Aneurysm Repair: A Systematic Review and Meta-analysis.”
— Effect of Statins on Total Mortality in Abdominal Aortic Aneurysm Repair: A Systematic Review and Meta-analysis. (2020)DOI“Effect of Statins on Total Mortality in Abdominal Aortic Aneurysm Repair: A Systematic Review and Meta-analysis”
— Effect of Statins on Total Mortality in Abdominal Aortic Aneurysm Repair: A Systematic Review and Meta-analysis (2021)DOI