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oxidative stress inhibition→renal ferroptosis prevention
Statins protect against diabetic nephropathy by inhibiting oxidative stress, ferroptosis, and inflammation in renal tissue beyond their lipid-lowering effects. Evidence quality is moderate with 40% support ratio and multiple clinical and experimental studies. This is a recognized but not formally approved use of statins.
“Statins play an important role in the treatment of diabetic nephropathy.”
— Long-term statins administration exacerbates diabetic nephropathy via ectopic fat deposition in diabetic mice. (2023)DOI“Our data support the notion that statins can inhibit diabetes-induced renal oxidative stress and ferroptosis, which may contribute to statins protection of diabetic nephropathy.”
— Atorvastatin ameliorates diabetic nephropathy through inhibiting oxidative stress and ferroptosis signaling. (2024)DOI“A serious consequence of diabetes is diabetic nephropathy (DN), which is commonly treated by statins.”
— The association between statin use and diabetic nephropathy in US adults: data from NHANES 2005 - 2018. (2024)DOI“Statin therapy for patients with diabetic nephropathy: balance between safety and efficacy of statin treatment for patients with impaired kidney function.”
— Statin therapy for patients with diabetic nephropathy: balance between safety and efficacy of statin treatment for patients with impaired kidney function. (2023)DOI