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cholesterol↓→amyloid↓, cerebrovascular protection
Statins may reduce dementia risk through anti-inflammatory, antioxidant, and cholesterol-lowering effects that attenuate cerebrovascular pathology and amyloid deposition. Evidence from 7 papers (latest 2023) includes both observational cohort data and interaction analyses showing neurocognitive baseline modifies statin benefit, suggesting a biologically plausible but heterogeneous effect.
“The statins have shown beneficial effects on cognitive functions and reduced the risk of dementia development.”
— Exploring the Genetic Associations Between the Use of Statins and Alzheimer's Disease. (2021)DOI“Baseline neurocognitive ability was an effect modifier for the associations of statins with dementia (p for interaction < 0.001) and memory change (p for interaction = 0.02).”
— Effect of Statin Therapy on Cognitive Decline and Incident Dementia in Older Adults. (2021)DOI“In NVAF patients who received OAC, statin therapy lowered the dementia risk compared with no statin therapy.”
— Statin therapy reduces dementia risk in atrial fibrillation patients receiving oral anticoagulants. (2023)DOI“In total, statins were shown to decrease the risk of dementia; however, no one statin subtype had such an effect.”
— Risk factors of dementia in patients with cerebral vascular diseases based on Taiwan National Health Insurance data. (2023)DOI“We sought to investigate the impact of statin therapy on dementia risk in AF patients receiving OAC.”
— Statin therapy reduces dementia risk in atrial fibrillation patients receiving oral anticoagulants. (2023)DOI“Effect of statins on cognitive decline and dementia A secondary analysis of data collected during a large randomised trial of aspirin looked at cognitive function in relation to the use of statins.”
— Scooting injuries . . . and other stories (2021)DOI