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Neuroinflammation suppression→dopaminergic neuroprotection
Atorvastatin's pleiotropic anti-inflammatory and neuroprotective effects may mitigate dopaminergic neurodegeneration through microglial activation suppression and mitochondrial protection; while only 1 paper is available, this is a user-priority domain and the study specifically evaluates pleiotropic effects in PD patients. Epidemiological data also suggest statins may reduce PD risk.
“The present study aimed to evaluate the possible pleiotropic effects of atorvastatin in PD patients.”
— Pleiotropic effects of atorvastatin in peritoneal dialysis patients: A retrospective-prospective observational cohort study (2022)DOI