Curcumin inhibits NOX2-derived superoxide production in activated microglia to suppress ROS-driven neuroinflammation.
Convergence: 73%3 bridgesneuroinflammation
Bridge Entities
CYBBA→B quality: 0.70B→C quality: 0.70
curcumin PARTICIPATES IN CYBB, which CONNECTED TO NOX2
A→B Evidence (5 total)
“In microglia, superoxide is produced through NADPH oxidase, specifically NOX2.”— Molecular Mechanisms of Alzheimer\\\'s Disease Induced by Amyloid-β and Tau Phosphorylation Along with RhoA Activity: Perspective of RhoA/Rho-Associated Protein Kinase Inhibitors for Neuronal Therapy. (2025)DOI
“We previously identified the contribution of the activation of microglial NADPH oxidase (NOX2) in rotenone-induced neurotoxicity.”— CD11b-NOX2 mutual regulation-mediated microglial exosome release contributes to rotenone-induced inflammation and neurotoxicity in BV2 microglia and primary cultures. (2024)DOI
NOX1A→B quality: 0.50B→C quality: 0.50
curcumin CO MENTIONED WITH NOX1, which CO MENTIONED WITH NOX2
NOX4A→B quality: 0.50B→C quality: 0.50
curcumin CO MENTIONED WITH NOX4, which CO MENTIONED WITH NOX2
Why This Is Novel
Only 2 papers mention both curcumin and NOX2. The CYBB pathway connecting them is largely uncharacterized.
Discovered by InTree.AI — analyzing 250M+ scientific papers