SGLT2 inhibitors → AIM2 — Novel Hypothesis | InTree.AI

Novel Hypothesis

SGLT2 inhibitorsAIM2

SGLT2 inhibitors inhibit AIM2 inflammasome to suppress cytosolic DNA sensing and pyroptosis

Convergence: 21%1 bridgeimmunology

Bridge Entities

NLRP3A→B quality: 0.70B→C quality: 0.70

SGLT2 inhibitors PARTICIPATES IN NLRP3, which CONNECTED TO AIM2

A→B Evidence (7 total)

“Pyroptosis was independent of the Nlrp3 and Nlrc4 inflammasome receptors but dependent on the inflammasome adaptor ASC and the cytosolic DNA sensor AIM2.”— Listeria monocytogenes triggers AIM2-mediated pyroptosis upon infrequent bacteriolysis in the macrophage cytosol. (2010)DOI

“Further, NLRC4 and AIM2 inflammasome activity were not affected, suggesting that DMSO is a selective inhibitor of the NLRP3 inflammasomes.”— Dimethyl sulfoxide inhibits NLRP3 inflammasome activation. (2014)DOI

Why This Is Novel

No published papers mention both SGLT2 inhibitors and AIM2 together. This connection is entirely inferred through NLRP3 — a genuinely unexplored hypothesis.

Discovered by InTree.AI — analyzing 250M+ scientific papers

Bridge Entities

Why This Is Novel

Under Maintenance

Bridge Entities

Why This Is Novel