BRCA1 → RAG1 — Novel Hypothesis | InTree.AI

Novel Hypothesis

BRCA1RAG1

BRCA1 regulates RAG1 function or fidelity during V(D)J recombination in lymphocyte development.

Convergence: 85%3 bridgesimmunology

Bridge Entities

RAG1/RAG2A→B quality: 0.70B→C quality: 0.70

BRCA1 PARTICIPATES IN RAG1/RAG2, which CONNECTED TO RAG1

A→B Evidence (48 total)

“RAG1 and RAG2 are essential for V(D)J recombination and lymphocyte development.”— Coordinate regulation of RAG1 and RAG2 by cell type-specific DNA elements 5\\\' of RAG2. (1999)DOI

“The roles of the RAG1 and RAG2 \\\"non-core\\\" regions in V(D)J recombination and lymphocyte development.”— The roles of the RAG1 and RAG2 \\\"non-core\\\" regions in V(D)J recombination and lymphocyte development. (2009)DOI

IRBPA→B quality: 0.50B→C quality: 0.50

BRCA1 CO MENTIONED WITH IRBP, which CO MENTIONED WITH RAG1

GHRA→B quality: 0.50B→C quality: 0.50

BRCA1 CO MENTIONED WITH GHR, which CO MENTIONED WITH RAG1

Why This Is Novel

5 papers mention both entities, but the specific connection through RAG1/RAG2 is underexplored — most co-mentions are incidental, not mechanistic.

Discovered by InTree.AI — analyzing 250M+ scientific papers