BRCA1 → NIK — Novel Hypothesis | InTree.AI

Novel Hypothesis

BRCA1NIK

BRCA1 regulates the alternative NF-κB pathway by controlling NIK (NF-κB-inducing kinase) activity.

Convergence: 72%3 bridgesimmunology

Bridge Entities

IKK complexA→B quality: 0.70B→C quality: 0.70

BRCA1 PARTICIPATES IN IKK complex, which CONNECTED TO NIK

A→B Evidence (3 total)

“The IkB kinases (IKKs) lie downstream of the NF-kBinducing kinase (NIK) and activate NF-kB by phosphorylation of IkBa.”— Differential I k B Kinase Activation and I k B a Degradation by Interleukin-1 b and Tumor Necrosis Factor-a in Human U 937 Monocytic Cells (1999)

“TRAIL‐induced NF‐kB activation was preceded by IkBα kinase (IKK) activation and IkBα degradation and depended on TRAF2, NF‐kB‐inducing kinase (NIK), IKK1, and IKK2.”— TRAIL‐mediated apoptosis requires NF‐kB inhibition and the mitochondrial permeability transition in human hepatoma cells (2002)DOI

HCC1937A→B quality: 0.50B→C quality: 0.50

BRCA1 CO MENTIONED WITH HCC1937, which CO MENTIONED WITH NIK

MCF-7A→B quality: 0.50B→C quality: 0.50

BRCA1 CO MENTIONED WITH MCF-7, which CO MENTIONED WITH NIK

Why This Is Novel

No published papers mention both BRCA1 and NIK together. This connection is entirely inferred through IKK complex — a genuinely unexplored hypothesis.

Discovered by InTree.AI — analyzing 250M+ scientific papers

Bridge Entities

Why This Is Novel

Under Maintenance

Bridge Entities

Why This Is Novel