Curcumin suppresses NF-κB p65 phosphorylation by inhibiting the IκB kinase beta (IKKβ) complex, reducing pro-inflammatory gene transcription.
Convergence: 77%3 bridgesneuroinflammation
Bridge Entities
IKBKGA→B quality: 0.70B→C quality: 0.70
curcumin PARTICIPATES IN IKBKG, which CONNECTED TO IKK
A→B Evidence (13 total)
“The protein expression of ROCK1, ROCK2, IKK, NF-κB, phosphorylated IKK(p-IKK), phosphorylated NF-κB(p-NF-κB), and phosphorylated inhibitor of NF-κB(p-IκB) increased(P<0.05), while the protein expression of inhibitor of NF-κB(IκB) decreased(P<0.05).”— [Mechanism of Zhenwu Decoction in improving renal inflammatory injury in mice with DN of spleen-kidney Yang deficiency syndrome by regulating ROCK/IKK/NF-κB pathway]. (2023)DOI
“The protein expression of ROCK1, ROCK2, IKK, NF-κB, phosphorylated IKK(p-IKK), phosphorylated NF-κB(p-NF-κB), and phosphorylated inhibitor of NF-κB(p-IκB) increased(P<0.05), while the protein expression of inhibitor of NF-κB(IκB) decreased(P<0.05).”— [Mechanism of Zhenwu Decoction in improving renal inflammatory injury in mice with DN of spleen-kidney Yang deficiency syndrome by regulating ROCK/IKK/NF-κB pathway]. (2023)DOI
COX-2A→B quality: 0.50B→C quality: 0.50
curcumin CO MENTIONED WITH COX-2, which CO MENTIONED WITH IKK
TANKA→B quality: 0.50B→C quality: 0.50
curcumin CO MENTIONED WITH TANK, which CO MENTIONED WITH IKK
Why This Is Novel
8 papers mention both entities, but the specific connection through IKBKG is underexplored — most co-mentions are incidental, not mechanistic.
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