rapamycin → HIF — Novel Hypothesis | InTree.AI

Novel Hypothesis

rapamycinHIF

Rapamycin inhibits mTORC1-mediated HIF-1α stabilization, reducing hypoxia-driven angiogenesis and metastasis in cancer.

Convergence: 80%3 bridgesoncology

Bridge Entities

HIF-1αA→B quality: 0.70B→C quality: 0.70

rapamycin PARTICIPATES IN HIF-1α, which CONNECTED TO HIF

A→B Evidence (12 total)

“The Distinct Role of HIF-1α and HIF-2α in Hypoxia and Angiogenesis.”— The Distinct Role of HIF-1α and HIF-2α in Hypoxia and Angiogenesis. (2025)DOI

MHY1485A→B quality: 0.50B→C quality: 0.50

rapamycin CO MENTIONED WITH MHY1485, which CO MENTIONED WITH HIF

LMP2AA→B quality: 0.50B→C quality: 0.50

rapamycin CO MENTIONED WITH LMP2A, which CO MENTIONED WITH HIF

Why This Is Novel

The rapamycin–HIF connection is partially studied (207 co-occurrences), but the HIF-1α-mediated mechanism may represent a less-explored angle within this relationship.

Discovered by InTree.AI — analyzing 250M+ scientific papers