Metformin → Cancer — Biological Pathway | InTree.AI

Biological Pathway

MetforminComplex I inhibited at mitochondrial inner membraneAMP:ATP ratio elevatedAMPK(Thr172) phosphorylated by LKB1mTORC1 kinase activity inhibitedHIF-1α mRNA translation reducedHIF-1α protein accumulation reducedVEGF-A transcription reducedtumor angiogenesis impairedoxygen and nutrient delivery to tumor mass reducedCancer

Score: 0.9010 hops

Pathway Hops

INHIBITSConfidence: 95%

ACTIVATESConfidence: 95%

PHOSPHORYLATESConfidence: 95%

INHIBITSConfidence: 95%

Discovered by InTree.AI — analyzing 250M+ scientific papers