curcumin → colorectal cancer — Biological Pathway | InTree.AI

Biological Pathway

curcuminγ-secretase-mediated Notch1 intracellular domain (NICD) cleavage inhibitedNICD nuclear translocation blockedCSL/RBPJ transcriptional complex activation reducedHes1 and Hey1 transcription reducedSNAIL1(Ser246) phosphorylation-dependent stabilization reducedE-cadherin transcriptional repression reversedE-cadherin(extracellular domain) surface expression elevatedβ-catenin membrane sequestration elevatedepithelial-mesenchymal transition markers vimentin and N-cadherin reducedcolorectal cancer

Score: 0.9010 hops

Pathway Hops

INHIBITSConfidence: 95%

ASSOCIATED WITHConfidence: 95%

INHIBITSConfidence: 95%

CAUSESConfidence: 95%

INDUCESConfidence: 95%

Discovered by InTree.AI — analyzing 250M+ scientific papers

Pathway Hops

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Pathway Hops