EGFR → apoptosis — Biological Pathway | InTree.AI

Biological Pathway

EGFRSOS1 activated via GRB2 adaptor bound to EGFR(pTyr1068)RAS(GTP-bound) elevatedRAF1(Ser338) phosphorylated and activatedMEK1/2(Ser217/Ser221) phosphorylated by RAF1ERK1/2(Thr202/Tyr204) phosphorylated by MEK1/2RSK1/2(Ser380) phosphorylated by ERK1/2BIM(EL)(Ser69) phosphorylated by ERK1/2BIM(EL) targeted for proteasomal degradation via SCF-βTrCPmitochondrial outer membrane permeabilization reducedapoptosis

Score: 0.9010 hops

Pathway Hops

INHIBITSConfidence: 95%

PHOSPHORYLATESConfidence: 95%

ASSOCIATED WITHConfidence: 95%

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