Metformin → Cancer — Biological Pathway | InTree.AI

Biological Pathway

MetforminComplex I inhibited at mitochondrial inner membraneAMP:ATP ratio elevatedAMPK(Thr172) phosphorylated by LKB1PTEN transcription elevated via AMPK-dependent mechanismsPIP3 levels at plasma membrane reducedAKT(Thr308/Ser473) phosphorylation reducedFOXO1/FOXO3a dephosphorylated and nuclearp27KIP1 (CDKN1B) transcription elevatedCDK2-cyclin E complex inhibitedG1/S cell cycle progression arrestedCancer

Score: 0.9011 hops

Pathway Hops

INHIBITSConfidence: 95%

ACTIVATESConfidence: 95%

PHOSPHORYLATESConfidence: 95%

INHIBITSConfidence: 95%

PHOSPHORYLATESConfidence: 95%

UPREGULATESConfidence: 95%

INHIBITSConfidence: 95%

Discovered by InTree.AI — analyzing 250M+ scientific papers