EGFRPLCγ1(Tyr783) phosphorylated and activatedPIP2 cleaved to DAG and IP3PKCα/β activated by DAG at plasma membranePKC phosphorylates IKKβ(Ser177)IκBα(Ser32/Ser36) phosphorylated and degradedNF-κB(p65) nuclear translocationBCL-2 transcription elevatedmitochondrial apoptosis suppressedapoptosis
Score: 0.909 hops
Pathway Hops
PHOSPHORYLATESConfidence: 95%
ACTIVATESConfidence: 95%
INHIBITSConfidence: 95%
INDUCESConfidence: 95%
PHOSPHORYLATESConfidence: 95%
PHOSPHORYLATESConfidence: 95%
INHIBITSConfidence: 95%
SUPPRESSESConfidence: 95%
INHIBITSConfidence: 95%
Discovered by InTree.AI — analyzing 250M+ scientific papers