aspirinsalicylate inhibits MDM2(RING domain) E3 ubiquitin ligase activityp53(Lys370/372/373/381/382) ubiquitination reducedp53 proteasomal degradation impairedp53(Ser15) stabilization elevatedp53 tetramerization and DNA binding activatedPUMA (BBC3) transcription upregulatedPUMA displaces BCL-2 from BAXBAX(Ser184) dephosphorylation-mediated conformational activationBAX N-terminus(6A7 epitope) exposed at outer mitochondrial membranecytochrome c release elevatedAPAF-1 apoptosome activatedcaspase-9(Asp315) cleavage elevatedcaspase-3(Asp175) cleavage elevatedinflammation Score: 0.8014 hops
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