curcumin → colorectal cancer — Biological Pathway | InTree.AI

Biological Pathway

curcumincurcumin inhibits PI3K p110α reducing PIP3 generationAKT(Thr308/Ser473) phosphorylation reducedFOXO3a(Ser253) dephosphorylated preventing 14-3-3-mediated cytoplasmic retentionFOXO3a nuclear translocation elevatedFOXO3a binds DBE motif in BIM promoter upregulating BIM(BCL2L11) transcriptionFOXO3a transactivates FASL promoter elevating FASL surface expressionFASL-FAS autocrine loop activates DISC-mediated caspase-8(Asp374) cleavageBIM protein accumulation displaces BAX from BCL-XLBAX-dependent cytochrome c release activates caspase-9(Asp315)caspase-3(Asp175) cleavage executes apoptosiscolorectal cancer

Score: 0.9011 hops

Pathway Hops

INHIBITSConfidence: 95%

PROMOTESConfidence: 95%

ACTIVATESConfidence: 95%

INDUCESConfidence: 95%

ACTIVATESConfidence: 95%

INHIBITSConfidence: 95%

Discovered by InTree.AI — analyzing 250M+ scientific papers

Pathway Hops

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Pathway Hops