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Biological Pathway
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curcumin
curcumin activates neutral sphingomyelinase (nSMase) at plasma membrane
sphingomyelin hydrolysis elevates ceramide(C16:0) in lipid rafts
ceramide activates PP2A(B56α) regulatory subunit dephosphorylating AKT(Ser473)
ceramide directly activates CASZ1/KSR1 scaffold reducing RAF-MEK-ERK(Thr202/Tyr204) flux
ceramide-enriched lipid raft platforms cluster FAS receptor facilitating DISC formation
ceramide activates cathepsin D in lysosomes cleaving BID to tBID independently of caspase-8
tBID-induced BAX(Ser184) dephosphorylation promotes mitochondrial insertion
cytochrome c release activates caspase-9(Asp315) via apoptosome
sphingosine-1-phosphate (S1P) production reduced by curcumin-suppressed SphK1(Thr193) phosphorylation removing pro-survival S1PR1 signalling
colorectal cancer
Score: 0.90
10 hops
Pathway Hops
INHIBITS
Confidence: 95%
ASSOCIATED WITH
Confidence: 95%
PHOSPHORYLATES
Confidence: 95%
PHOSPHORYLATES
Confidence: 95%
ASSOCIATED WITH
Confidence: 95%
ASSOCIATED WITH
Confidence: 95%
ASSOCIATED WITH
Confidence: 95%
ACTIVATES
Confidence: 95%
INHIBITS
Confidence: 95%
PHOSPHORYLATES
Confidence: 95%
Discovered by InTree.AI — analyzing 250M+ scientific papers
curcumin → colorectal cancer — Biological Pathway | InTree.AI | InTree