aspirinadenylyl cyclase(AC) activity elevated by salicylate in leukocytescAMP levels elevatedPKA catalytic subunit(Thr197) autophosphorylated and activatedCREB(Ser133) phosphorylated by PKAIL-10 transcription elevatedSTAT3(Tyr705)-independent anti-inflammatory signaling elevatedTNF-α and IL-12 production from macrophages suppressedinflammation
Score: 0.908 hops
Pathway Hops
INHIBITSConfidence: 95%
INHIBITSConfidence: 95%
INHIBITSConfidence: 95%
PHOSPHORYLATESConfidence: 95%
PHOSPHORYLATESConfidence: 95%
SUPPRESSESConfidence: 95%
SUPPRESSESConfidence: 95%
INHIBITSConfidence: 95%
Discovered by InTree.AI — analyzing 250M+ scientific papers