MetforminComplex I inhibited at mitochondrial inner membraneAMP:ATP ratio elevatedLKB1 (STK11) required for AMPK(Thr172) phosphorylationLKB1-deficient tumor cells unable to activate AMPKenergy stress tolerance mechanisms absent in LKB1-null cellsmitochondrial membrane potential collapse elevatedcytochrome c released from mitochondriacaspase-9(Asp315) cleavedcaspase-3(Asp175) cleavedCancer
Score: 0.9010 hops
Pathway Hops
INHIBITSConfidence: 95%
INHIBITSConfidence: 95%
ACTIVATESConfidence: 95%
PHOSPHORYLATESConfidence: 95%
ACTIVATESConfidence: 95%
PROMOTESConfidence: 95%
ASSOCIATED WITHConfidence: 95%
ACTIVATESConfidence: 95%
INDUCESConfidence: 95%
INDUCESConfidence: 95%
Discovered by InTree.AI — analyzing 250M+ scientific papers
Metformin → Cancer — Biological Pathway | InTree.AI | InTree