MetforminComplex I inhibited at mitochondrial inner membraneelectron transport chain partial blockade elevates superoxide generationmitochondrial ROS (O2•−) elevatedoxidative stress-induced BAX conformational activationBAX oligomerization at outer mitochondrial membranemitochondrial outer membrane permeabilizationcytochrome c released into cytosolAPAF-1 apoptosome assembledcaspase-9(Asp315) cleavedcaspase-3(Asp175) cleavedCancer Score: 0.9011 hops
Pathway Hops
SUPPRESSESConfidence: 95%
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