Metformin → Cancer — Biological Pathway | InTree.AI

Biological Pathway

MetforminComplex I inhibited at mitochondrial inner membraneelectron transport chain partial blockade elevates superoxide generationmitochondrial ROS (O2•−) elevatedoxidative stress-induced BAX conformational activationBAX oligomerization at outer mitochondrial membranemitochondrial outer membrane permeabilizationcytochrome c released into cytosolAPAF-1 apoptosome assembledcaspase-9(Asp315) cleavedcaspase-3(Asp175) cleavedCancer

Score: 0.9011 hops

Pathway Hops

INHIBITSConfidence: 95%

INDUCESConfidence: 95%

PROMOTESConfidence: 95%

CAUSESConfidence: 95%

INHIBITSConfidence: 95%

SUPPRESSESConfidence: 95%

INDUCESConfidence: 95%

Discovered by InTree.AI — analyzing 250M+ scientific papers

Pathway Hops

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Pathway Hops