Metformin → Cancer — Biological Pathway | InTree.AI

Biological Pathway

MetforminComplex I (NADH dehydrogenase) inhibited at mitochondrial inner membraneAMP:ATP ratio elevatedAMPK(Thr172) phosphorylated by LKB1TSC2(Thr1227/Ser1345) phosphorylated by AMPKTSC1-TSC2 complex GAP activity toward Rheb elevatedRheb-GTP hydrolyzed to Rheb-GDPmTORC1 kinase activity inhibitedS6K1(Thr389) phosphorylation reduced4EBP1(Thr37/Thr46) dephosphorylatedcap-dependent translation of cyclin D1 and c-Myc mRNAs reducedCancer

Score: 0.9011 hops

Pathway Hops

INHIBITSConfidence: 95%

ACTIVATESConfidence: 95%

PHOSPHORYLATESConfidence: 95%

ACTIVATESConfidence: 95%

INHIBITSConfidence: 95%

PHOSPHORYLATESConfidence: 95%

INHIBITSConfidence: 95%

Discovered by InTree.AI — analyzing 250M+ scientific papers