aspirin → inflammation — Biological Pathway | InTree.AI

Biological Pathway

aspirinCOX-1(Ser530) irreversible acetylation by aspirinthromboxane A2 (TXA2) synthesis reducedTP receptor (TBXA2R) signaling attenuatedGα12/13-RhoA axis activation impairedIKKβ(Ser177/181) phosphorylation reducedIκBα(Ser32/36) phosphorylation diminishedIκBα degradation by SCF-βTrCP E3 ligase blockedNF-κB(p65/p50) nuclear translocation reducedIL-6/TNF-α/IL-1β transcription suppressedinflammation

Score: 0.9010 hops

Pathway Hops

ACETYLATESConfidence: 95%

INDUCESConfidence: 95%

SUPPRESSESConfidence: 95%

PHOSPHORYLATESConfidence: 95%

INHIBITSConfidence: 95%

Discovered by InTree.AI — analyzing 250M+ scientific papers