curcumincurcumin-mediated ROS elevation depolarises mitochondrial membrane potential (ΔΨm reduced)BAX(Ser184) dephosphorylation promotes BAX conformational activationBAX/BAK heterooligomers form MOMP pore at outer mitochondrial membranecytochrome c released into cytosolAPAF1 WD40 domain binds cytochrome c triggering APAF1 oligomerisationheptameric apoptosome recruits procaspase-9 via CARD–CARD interactioncaspase-9(Asp315) autoprocessing activated within apoptosomecaspase-3(Asp175) cleaved by active caspase-9ICAD(Asp117/Asp224) cleaved by caspase-3 releasing CAD nucleaseCAD-mediated internucleosomal DNA fragmentationcolorectal cancer
Score: 0.9011 hops
Pathway Hops
CAUSESConfidence: 95%
CAUSESConfidence: 95%
PROMOTESConfidence: 95%
CAUSESConfidence: 95%
BINDS TOConfidence: 95%
ACTIVATESConfidence: 95%
ACTIVATESConfidence: 95%
ACTIVATESConfidence: 95%
ACTIVATESConfidence: 95%
ACTIVATESConfidence: 95%
INHIBITSConfidence: 95%
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