MetforminComplex I inhibited at mitochondrial inner membraneAMP:ATP ratio elevatedAMPK(Thr172) phosphorylated by LKB1IKKβ(Ser180) phosphorylation reducedIκBα degradation impairedNF-κB(p65) nuclear translocation reducedIL-6, TNF-α, and COX-2 transcription reducedSTAT3(Tyr705) phosphorylation reducedBCL-XL and survivin transcription reducedapoptosis resistance in tumor microenvironment diminishedCancer
Score: 0.9011 hops
Pathway Hops
INHIBITSConfidence: 95%
INHIBITSConfidence: 95%
ACTIVATESConfidence: 95%
PHOSPHORYLATESConfidence: 95%
PHOSPHORYLATESConfidence: 95%
PHOSPHORYLATESConfidence: 95%
INHIBITSConfidence: 95%
PHOSPHORYLATESConfidence: 95%
PHOSPHORYLATESConfidence: 95%
INHIBITSConfidence: 95%
INHIBITSConfidence: 95%
Discovered by InTree.AI — analyzing 250M+ scientific papers
Metformin → Cancer — Biological Pathway | InTree.AI | InTree