Metformin → Cancer — Biological Pathway | InTree.AI

Biological Pathway

MetforminComplex I inhibited at mitochondrial inner membraneAMP:ATP ratio elevatedAMPK(Thr172) phosphorylated by LKB1IKKβ(Ser180) phosphorylation reducedIκBα degradation impairedNF-κB(p65) nuclear translocation reducedIL-6, TNF-α, and COX-2 transcription reducedSTAT3(Tyr705) phosphorylation reducedBCL-XL and survivin transcription reducedapoptosis resistance in tumor microenvironment diminishedCancer

Score: 0.9011 hops

Pathway Hops

INHIBITSConfidence: 95%

ACTIVATESConfidence: 95%

PHOSPHORYLATESConfidence: 95%

INHIBITSConfidence: 95%

PHOSPHORYLATESConfidence: 95%

INHIBITSConfidence: 95%

Discovered by InTree.AI — analyzing 250M+ scientific papers