EGFR → apoptosis — Biological Pathway | InTree.AI

Biological Pathway

EGFRPI3K(p110α) activated by EGFR-bound GRB2-GAB1 complexPIP3 elevated at inner leaflet of plasma membranePDK1(Ser241) autophosphorylated and recruited to PIP3AKT(Thr308) phosphorylated by PDK1AKT(Ser473) phosphorylated by mTORC2BAD(Ser136) phosphorylated by AKTBAD sequestered by 14-3-3ζ protein in cytoplasmBCL-2 freed from BAD at mitochondrial outer membranecytochrome c release from mitochondria blockedcaspase-9(Asp315) activation impairedapoptosis

Score: 0.9011 hops

Pathway Hops

ACTIVATESConfidence: 95%

UPREGULATESConfidence: 95%

ACTIVATESConfidence: 95%

PHOSPHORYLATESConfidence: 95%

CAUSESConfidence: 95%

PREVENTSConfidence: 95%

INHIBITSConfidence: 95%

PROMOTESConfidence: 95%

Discovered by InTree.AI — analyzing 250M+ scientific papers