EGFREGFR activatedPI3K/AKTHIF-1α(Pro402/564) hydroxylation inhibited by reduced PHD2 activityHIF-1α stabilisedHIF-1α/ARNT heterodimer nuclear → BNIP3 transcription upregulatedBNIP3 protein elevated → mitochondrial membrane potential (ΔΨm) dissipatedBNIP3 BH3-only domain displaces BCL-2/BCL-XL from BAX/BAKBAX(Ser184) unphosphorylated → BAX oligomers inserted into OMMcytochrome c released → APAF1 apoptosome assembledcaspase-9(Asp315) cleaved → caspase-3(Asp175) cleavedapoptosis Score: 0.9011 hops
Pathway Hops
UPREGULATESConfidence: 95%
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