aspirinaspirin activates acid sphingomyelinase (ASMase) in lysosomessphingomyelin hydrolysis to ceramide elevatedceramide activates protein phosphatase 2A (PP2A) catalytic subunitPP2A dephosphorylates AKT(Thr308/Ser473)AKT kinase activity impairedBAD(Ser136) dephosphorylation by PP2A elevatedBAD releases from 14-3-3 protein sequestrationBAD BH3 domain binds BCL-2/BCL-XLBAX freed from BCL-2 inhibitionBAX oligomerization and cytochrome c release elevatedinflammation Score: 0.9011 hops
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