aspirinMDM2 E3 ligase activity reduced by aspirinp53 protein level stabilizedNOXA (PMAIP1) transcription elevatedNOXA BH3 domain binds MCL-1(BH3-binding groove)MCL-1/BAK complex dissociatedBAK(Thr163) dephosphorylation allows oligomerizationBAK homo-oligomers form pores in outer mitochondrial membranecytochrome c release elevatedcaspase-9(Asp315) cleavage elevatedinflammation Score: 0.9010 hops
Pathway Hops
SUPPRESSESConfidence: 95%
ASSOCIATED WITHConfidence: 95%
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