aspirinaspirin-mediated NF-κB suppression reduces c-FLIP(L) transcriptionc-FLIP(L) protein level at DISC reducedFAS(CD95) DISC assembly with FADD unopposedprocaspase-8(Asp374/384) homodimerization and cleavage at DISC elevatedactive caspase-8 cleaves BID(Asp59) to tBIDtBID inserts into OMM activating BAX/BAKBAX(Ser184) dephosphorylation stabilizes active conformationcytochrome c / SMAC released from mitochondriaXIAP(BIR3 domain) antagonized by SMAC(AVPI motif)caspase-9(Asp315) and caspase-3(Asp175) cleavage elevatedinflammation
Score: 0.9011 hops
Pathway Hops
SUPPRESSESConfidence: 95%
DOWNREGULATESConfidence: 95%
PROMOTESConfidence: 95%
ACTIVATESConfidence: 95%
ACTIVATESConfidence: 95%
CAUSESConfidence: 95%
ACTIVATESConfidence: 95%
CAUSESConfidence: 95%
ASSOCIATED WITHConfidence: 95%
CAUSESConfidence: 95%
INHIBITSConfidence: 95%
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