aspirin → inflammation — Biological Pathway | InTree.AI

Biological Pathway

aspirinaspirin uncouples mitochondrial electron transport chainsuperoxide anion (O2•−) generation elevated at complex I/IIImitochondrial ROS oxidize Trx1(Cys32/Cys35) disulfide bondTrx1 dissociates from ASK1(Thr838) releasing inhibitionASK1 homodimerization and autophosphorylation at Thr838 elevatedMKK4(Ser257/Thr261) and MKK7(Ser271/Thr275) phosphorylation by ASK1JNK(Thr183/Tyr185) phosphorylation elevatedBIM(Ser69/Thr116) phosphorylation by JNK prevents proteasomal turnoverBIM accumulation at OMM displaces BCL-2 from BAXBAX-dependent cytochrome c release elevatedinflammation

Score: 0.9011 hops

Pathway Hops

UNCOUPLESConfidence: 95%

CAUSESConfidence: 95%

ACTIVATESConfidence: 95%

PHOSPHORYLATESConfidence: 95%

CAUSESConfidence: 95%

Discovered by InTree.AI — analyzing 250M+ scientific papers