EGFR → apoptosis — Biological Pathway | InTree.AI

Biological Pathway

EGFRRAS-GTP elevated downstream of EGFRRAF1 activatedMEK1/2 phosphorylatedERK1/2(Thr202/Tyr204) phosphorylatedERK1/2 phosphorylates caspase-9(Thr125)caspase-9(Thr125) phosphorylation blocks Asp315 cleavagecaspase-9 catalytic activity inhibitedcaspase-3(Asp175) cleavage impairedapoptosis

Score: 0.909 hops

Pathway Hops

ACTIVATESConfidence: 95%

PHOSPHORYLATESConfidence: 95%

INHIBITSConfidence: 95%

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