curcumin → colorectal cancer — Biological Pathway | InTree.AI

Biological Pathway

curcuminMDM2(Ser166) autophosphorylation inhibitedMDM2-mediated ubiquitination of p53(Lys370/Lys372/Lys373) reducedp53 proteasomal degradation blockedp53(Ser15) phosphorylation elevated via ATM activationp53 nuclear accumulation elevatedPUMA and NOXA transcription elevatedPUMA binds BCL-2 at mitochondriaBAX(Ser184) conformational activation elevatedcytochrome c releasedcaspase-9(Asp315) cleavedcolorectal cancer

Score: 0.9011 hops

Pathway Hops

INHIBITSConfidence: 95%

CAUSESConfidence: 95%

INHIBITSConfidence: 95%

PHOSPHORYLATESConfidence: 95%

INHIBITSConfidence: 95%

INDUCESConfidence: 95%

INHIBITSConfidence: 95%

INDUCESConfidence: 95%

Discovered by InTree.AI — analyzing 250M+ scientific papers

Pathway Hops

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Pathway Hops