Metformin → Cancer — Biological Pathway | InTree.AI

Biological Pathway

MetforminComplex I inhibited at mitochondrial inner membraneAMP:ATP ratio elevatedAMPK(Thr172) phosphorylated by LKB1ACC1(Ser79)/ACC2(Ser212) phosphorylated by AMPKmalonyl-CoA synthesis reducedFASN substrate supply reducedde novo fatty acid synthesis inhibitedmembrane lipid biosynthesis for rapidly proliferating cells reducedproliferative signaling support diminishedCancer

Score: 0.9010 hops

Pathway Hops

INHIBITSConfidence: 95%

ACTIVATESConfidence: 95%

PHOSPHORYLATESConfidence: 95%

CAUSESConfidence: 95%

INHIBITSConfidence: 95%

DOWNREGULATESConfidence: 95%

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