EGFREGFR activated → AKT(Ser473) phosphorylated → MDM2(Ser166/186) phosphorylatedMDM2 nuclear import elevatedp53(Lys382) ubiquitinatedp53 proteasomal degradation elevatedEGFR inhibitionAKT activity reducedMDM2(Ser166) dephosphorylatedp53 stabilisedp53(Ser15) phosphorylated by ATM/ATR → p53 transcriptional activity elevatedp53 → PUMA(BBC3) transcription upregulated → BCL-XL/BCL-2 BH3-groove occupiedBAX released from BCL-2 sequestrationBAX(Ser184) unphosphorylatedBAX oligomerised at OMMcytochrome c released → APAF1 apoptosome assembled → caspase-9(Asp315) cleavedcaspase-3(Asp175) cleavedapoptosis Score: 0.8016 hops
Discovered by InTree.AI — analyzing 250M+ scientific papers