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Biological Pathway
Cite
curcumin
curcumin upregulates FAS(CD95) surface expression on colorectal cancer cells
FASL(CD95L) autocrine/paracrine binding to FAS receptor
FAS receptor trimerisation recruits FADD via DD–DD homotypic interaction
FADD DED domain recruits procaspase-8 forming DISC
procaspase-8(Asp374/Asp384) cleavage generates active caspase-8 heterotetramer
active caspase-8 cleaves BID(Asp59) to tBID
tBID translocates to mitochondria activating BAX/BAK oligomerisation
cytochrome c/SMAC co-release into cytosol
APAF1 apoptosome-mediated caspase-9(Asp315) activation
caspase-3(Asp175) and caspase-6(Asp179) cleavage
colorectal cancer
Score: 0.90
11 hops
Pathway Hops
UPREGULATES
Confidence: 95%
UPREGULATES
Confidence: 95%
INDUCES
Confidence: 95%
RECRUITS
Confidence: 95%
ACTIVATES
Confidence: 95%
CLEAVES
Confidence: 95%
ACTIVATES
Confidence: 95%
INDUCES
Confidence: 95%
ACTIVATES
Confidence: 95%
ACTIVATES
Confidence: 95%
INHIBITS
Confidence: 95%
Discovered by InTree.AI — analyzing 250M+ scientific papers