aspirin → inflammation — Biological Pathway | InTree.AI

Biological Pathway

aspirinCOX-2(Ser516) acetylation reduces PGE2 synthesisEP2/EP4 receptor signaling attenuatedcAMP/PKA(Thr197) axis reducedNF-κB(p65) survival gene transcription diminishedDR5 (TNFRSF10B) promoter de-repressed by loss of NF-κB occupancyDR5 surface expression elevatedTRAIL(TNFSF10) binding to DR5 enhancedDISC assembly: FADD(DED domain) recruitedprocaspase-8(Asp374/384) cleavage at DISC activatedBID(Asp59) cleavage to tBIDBAX/BAK oligomerization at OMMcytochrome c release elevatedinflammation

Score: 0.9013 hops

Pathway Hops

SUPPRESSESConfidence: 95%

INHIBITSConfidence: 95%

PREVENTSConfidence: 95%

UPREGULATESConfidence: 95%

CAUSESConfidence: 95%

ACTIVATESConfidence: 95%

CAUSESConfidence: 95%

Discovered by InTree.AI — analyzing 250M+ scientific papers