aspirinKeap1(Cys151/Cys273) modified by aspirin-derived reactive speciesNrf2 dissociation from Keap1 elevatedNrf2(Ser40) phosphorylation by PKCδ elevatedNrf2 nuclear translocation and ARE binding elevatedHO-1 and NQO1 transcription elevatedbiliverdin and CO production elevatedNF-κB(p65) nuclear accumulation suppressed by COmacrophage M2 polarization favoredinflammation
Score: 0.909 hops
Pathway Hops
INHIBITSConfidence: 95%
CAUSESConfidence: 95%
CAUSESConfidence: 95%
INDUCESConfidence: 95%
INDUCESConfidence: 95%
SUPPRESSESConfidence: 95%
SUPPRESSESConfidence: 95%
INHIBITSConfidence: 95%
INHIBITSConfidence: 95%
Discovered by InTree.AI — analyzing 250M+ scientific papers