curcumin → colorectal cancer — Biological Pathway | InTree.AI

Biological Pathway

curcuminEGFR(Tyr1068) autophosphorylation inhibitedSOS1-mediated RAS(GTP) loading reducedRAF1(Ser338) activating phosphorylation reducedMEK1/MEK2(Ser217/Ser221) phosphorylation reducedERK1/ERK2(Thr202/Tyr204) phosphorylation reducedRSK2(Ser380) phosphorylation reducedCREB(Ser133) phosphorylation reducedcyclin D1 transcription reducedG1 cell cycle arrest elevatedCDK4/CDK6 activity reducedcolorectal cancer

Score: 0.9011 hops

Pathway Hops

PHOSPHORYLATESConfidence: 95%

INHIBITSConfidence: 95%

PHOSPHORYLATESConfidence: 95%

INDUCESConfidence: 95%

INHIBITSConfidence: 95%

Discovered by InTree.AI — analyzing 250M+ scientific papers

Pathway Hops

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Pathway Hops