EGFRPI3K activated by EGFRAKT(Ser473) phosphorylatedIKKα/β(Ser176/Ser177) phosphorylated by AKTIκBα(Ser32/Ser36) phosphorylated by IKKβIκBα ubiquitinated and degraded by 26S proteasomeNF-κB(p65/p50) translocates to nucleusBCL-2 and BCL-XL transcription elevatedXIAP transcription elevatedcaspase cascade inhibitedapoptosis
Score: 0.9010 hops
Pathway Hops
INHIBITSConfidence: 95%
PHOSPHORYLATESConfidence: 95%
PHOSPHORYLATESConfidence: 95%
PHOSPHORYLATESConfidence: 95%
INHIBITSConfidence: 95%
INHIBITSConfidence: 95%
INHIBITSConfidence: 95%
SUPPRESSESConfidence: 95%
INHIBITSConfidence: 95%
INHIBITSConfidence: 95%
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