aspirin → inflammation — Biological Pathway | InTree.AI

Biological Pathway

aspirinAMPK(Thr172) activated by aspirin/salicylateNAD+/NADH ratio elevatedSIRT1 deacetylase activity enhancedNF-κB(p65/Lys310) deacetylated by SIRT1p65 transcriptional co-activator binding impairedTNF-α and IL-6 promoter occupancy by p65 reducedmacrophage inflammatory polarization (M1) suppressedinflammation

Score: 0.908 hops

Pathway Hops

INHIBITSConfidence: 95%

ACETYLATESConfidence: 95%

INHIBITSConfidence: 95%

SUPPRESSESConfidence: 95%

INHIBITSConfidence: 95%

Discovered by InTree.AI — analyzing 250M+ scientific papers