EGFR → apoptosis — Biological Pathway | InTree.AI

Biological Pathway

EGFRPI3K(p110α) activated by EGFRAKT(Thr308/Ser473) phosphorylatedGSK3β(Ser9) phosphorylated and inactivated by AKTMCL-1(Ser159/Thr163) phosphorylation by GSK3β blockedMCL-1 ubiquitination by FBXW7 impairedMCL-1 protein stabilizedBAK sequestered at mitochondria by MCL-1cytochrome c release blockedapoptosis

Score: 0.909 hops

Pathway Hops

INHIBITSConfidence: 95%

PHOSPHORYLATESConfidence: 95%

CAUSESConfidence: 95%

INHIBITSConfidence: 95%

Discovered by InTree.AI — analyzing 250M+ scientific papers