MetforminComplex I inhibited at mitochondrial inner membraneAMP:ATP ratio elevatedAMPK(Thr172) phosphorylated by LKB1p27KIP1(Thr198) phosphorylated by AMPKp27KIP1 stabilized against SCF-SKP2 ubiquitinationCDK2-cyclin E(Thr160) kinase activity inhibitedRB1(Ser780/Ser795) phosphorylation reducedE2F1-dependent transcription of proliferative genes reducedG1 arrest in tumor cells elevatedCancer
Score: 0.9010 hops
Pathway Hops
INHIBITSConfidence: 95%
INHIBITSConfidence: 95%
ACTIVATESConfidence: 95%
PHOSPHORYLATESConfidence: 95%
ACTIVATESConfidence: 95%
PHOSPHORYLATESConfidence: 95%
PHOSPHORYLATESConfidence: 95%
PHOSPHORYLATESConfidence: 95%
INHIBITSConfidence: 95%
INHIBITSConfidence: 95%
Discovered by InTree.AI — analyzing 250M+ scientific papers
Metformin → Cancer — Biological Pathway | InTree.AI | InTree