aspirin → inflammation — Biological Pathway | InTree.AI

Biological Pathway

aspirinCOX-2(Ser516) acetylation shunts arachidonate toward 5-LOXFLAP(5-LOX activating protein) availability unchanged but substrate redirected5-LOX(Ser663) phosphorylation by MAPK unchangedLTA4 hydrolase-mediated LTB4 synthesis transiently elevated then resolvedBLT1/BLT2 receptor signaling on neutrophils elevated then desensitizedPKCδ(Thr505) phosphorylation in neutrophils reducedneutrophil degranulation and elastase release reducedinflammation

Score: 0.908 hops

Pathway Hops

ACETYLATESConfidence: 95%

ACTIVATESConfidence: 95%

INHIBITSConfidence: 95%

ASSOCIATED WITHConfidence: 95%

INHIBITSConfidence: 95%

Discovered by InTree.AI — analyzing 250M+ scientific papers