MetforminMetformin activates AMPK(Thr172) via Complex I inhibitionAMPK(Thr172)-phosphorylated activity elevates DR5(TNFRSF10B) transcription via p53-independent NF-κB-suppressed de-repressionDR5(TNFRSF10B) surface expression elevatedTRAIL(TNFSF10) binding to DR5 homotrimerDISC assembly: FADD(DD domain) recruited to DR5(DD domain)procaspase-8 dimerisation at DISC → cleavage at Asp374/Asp384active caspase-8 cleaves BID(Asp59) generating tBIDtBID inserts into OMM displacing BCL-XL from BAXBAX(Ser184)-dephosphorylated conformational change → BAX oligomerisation at OMMcytochrome c released into cytosolCancer
Score: 0.7011 hops
Pathway Hops
ACTIVATESConfidence: 95%
UPREGULATESConfidence: 95%
UPREGULATESConfidence: 95%
BINDS TOConfidence: 95%
INDUCESConfidence: 95%
ACTIVATESConfidence: 95%
ACTIVATESConfidence: 95%
CAUSESConfidence: 95%
ACTIVATESConfidence: 95%
CAUSESConfidence: 95%
PREVENTSConfidence: 95%
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Metformin → Cancer — Biological Pathway | InTree.AI | InTree